Acute Coronary Syndromes: From Pathophysiological Pathways to Pharmacological Challenge

نویسنده

  • Gianluca Di Micco
چکیده

The clinical presentation of ischaemic heart disease includes stable and unstable angina pectoris, silent ischaemia, myocardial infarction, heart failure and sudden death [1]. For many years, unstable angina has been considered an intermediate syndrome between chronic stable angina and acute myocardial infarction. In recent years, its pathophysiology has been clarified and acute coronary syndrome (ACS) is now a common term for unstable angina pectoris and evolving myocardial infarction (MI) [2]. Two different syndromes outline, distinguished in ST elevation and non ST elevation coronary diseases [3].

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Pathophysiological role of neutrophils in acute myocardial infarction.

The pathogenesis of acute myocardial infarction is known to be mediated by systemic, intraplaque and myocardial inflammatory processes. Among different immune cell subsets, compelling evidence now indicates a pivotal role for neutrophils in acute coronary syndromes. Neutrophils infiltrate coronary plaques and the infarcted myocardium and mediate tissue damage by releasing matrix-degrading enzym...

متن کامل

Invasive coronary revascularisation is better than conservative treatment in patients with acute coronary syndromes.

New advances in interventional cardiology and antithrombotic pharmacological treatment have modified the risk:benefit ratio of percutaneous interventions in acute coronary syndromes without ST segment elevation. In general terms, invasive strategies have two main limitations. The first stems from the fact that the severity of a coronary stenosis is not an index of the likelihood of the developm...

متن کامل

Acute coronary syndromes: should women receive less antithrombotic medication than men?

A recent meta-analysis of all randomised trials assessing the efficacy and safety of glycoprotein IIb/IIIa agents with acute coronary syndromes showed that there was a significant interaction with sex. Explaining this difference requires an analysis of whether it has any pathophysiological basis, whether antithrombotic medications are indeed less efficacious in women in different clinical situa...

متن کامل

Prognostic value of C-Reactive Protein in Acute Coronary Syndromes

Introduction: Coronary artery disease (CAD) is among the most common, serious, chronic and life- threatening illnesses in the world. CAD represents a spectrum of conditions, with acute myocardial infarction at one end of it and silent ischemia at the other. There is growing evidence on importance of prognosis of C- reactive protein (CPR) in unstable angina and this protein is a maker of an adve...

متن کامل

Behavioral and emotional triggers of acute coronary syndromes: a systematic review and critique.

OBJECTIVE The objective of this study was to review the evidence that behavioral and emotional factors are triggers of acute coronary syndromes. METHOD Systematic review of the published literature from 1970 to 2004 of trigger events, defined as stimuli or activities occurring within 24 hours of the onset of acute coronary syndromes. RESULTS There is consistent evidence that physical exerti...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2009